Line Emission from an Accretion Disk around a Rotating Black Hole: Toward a Measurement of Frame Dragging

Line emission from an accretion disk and a corotating hot spot about a rotating black hole are considered for possible signatures of the frame-dragging effect. We explicitly compare integrated line profiles from a geometrically thin disk about a Schwarzschild and an extreme Kerr black hole, and show that the line profile differences are small if the inner radius of the disk is near or above the Schwarzschild stable-orbit limit of radius 6GM/c^2. However, if the inner disk radius extends below this limit, as is possible in the extreme Kerr spacetime, then differences can become significant, especially if the disk emissivity is stronger near the inner regions. We demonstrate that the first three moments of a line profile define a three-dimensional space in which the presence of material at small radii becomes quantitatively evident in broad classes of disk models. In the context of the simple, thin disk paradigm, this moment-mapping scheme suggests formally that the iron line detected by the Advanced Satellite for Cosmology and Astrophysics mission from MCG-6-30-15 (Tanaka et al. 1995) is 3 times more likely to originate from a disk about a rotating black hole than from a Schwarzschild system. A statistically significant detection of black hole rotation in this way may be achieved after only modest improvements in the quality of data. We also consider light curves and frequency shifts in line emission as a function of time for corotating hot spots in extreme Kerr and Schwarzschild geometries. Both the frequency-shift profile and the light curve from a hot spot are valuable measures of orbital parameters and might possibly be used to detect frame dragging even at radii approaching 6GM/c^2 if the inclination angle of the orbital plane is large.Comment: 15 pages (LaTex), 7 postscript figures; color plot (Figure 1) available at http://cfata2.harvard.edu/bromley/nu_nofun.html (This version contains a new subsection as well as minor corrections.

Unilateral hamstring foam rolling does not impair strength but the rate of force development of the contralateral muscle

Background Self-administered foam rolling (SAFR) is an effective massage technique often used in sport and rehabilitation settings to improve range of motion (ROM) without impairing the strength performance. However, the effects of unilateral SAFR on contralateral non-intervened muscle’s rate of force development (RFD) are unknown. Therefore, the purpose of this investigation was to examine the acute effects of unilateral hamstrings SAFR on the contralateral limb flexibility, the isometric strength, and the RFD parameters. Methods Thirty-four subjects (21 women) completed two separate randomly sequenced experimental visits, during which the control (rested for 10 min) or ten, 30-second SAFR were performed with the dominant hamstring muscle group. Before (Pre) and after (Post) the interventions, the contralateral hip flexion passive ROM, the maximal explosive isometric strength of the contralateral knee flexors with the corresponding prime mover muscles’ surface electromyographic (EMG) amplitude were measured. Separate two-way (time ×intervention) repeated measures analyses of variance (ANOVAs) were used to examine the potential changes of the dependent variables. Results The SAFR significantly improved the contralateral limb ROM (Pre vs. Post: 68.3 ± 21.0 vs. 73.2 ± 23.2 degrees, p < 0.001; d = 0.22). No change was found for the contralateral isometric strength or the maximal EMG amplitude. For the RFD parameters, the percent changes of the RFDs for the first 50, 100, and 200 ms of the maximal explosive isometric contraction were −31.2%, −16.8%, and −10.1%, respectively, following the unilateral SAFR, relative to the control condition. In addition, the decrement of the first 50-ms RFD reached statistical significance (p = 0.007; Cohen’s d = 0.44). Conclusion Ten sets of 30-second unilateral hamstring SAFR improved the ROM of the non-intervened contralateral limb, but decreased its ability to generate force, especially during the early phase (e.g., 50 ms) of the maximal explosive contraction

GRASP: Accelerating Shortest Path Attacks via Graph Attention

Recent advances in machine learning (ML) have shown promise in aiding and accelerating classical combinatorial optimization algorithms. ML-based speed ups that aim to learn in an end to end manner (i.e., directly output the solution) tend to trade off run time with solution quality. Therefore, solutions that are able to accelerate existing solvers while maintaining their performance guarantees, are of great interest. We consider an APX-hard problem, where an adversary aims to attack shortest paths in a graph by removing the minimum number of edges. We propose the GRASP algorithm: Graph Attention Accelerated Shortest Path Attack, an ML aided optimization algorithm that achieves run times up to 10x faster, while maintaining the quality of solution generated. GRASP uses a graph attention network to identify a smaller subgraph containing the combinatorial solution, thus effectively reducing the input problem size. Additionally, we demonstrate how careful representation of the input graph, including node features that correlate well with the optimization task, can highlight important structure in the optimization solution

Intimate Relationship Dynamics and Changing Desire for Pregnancy Among Young Women

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151900/1/psrh12119_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151900/2/psrh12119.pd

Pherotype polymorphism in Streptococcus pneumoniae has no obvious effects on population structure and recombination

Natural transformation in the Gram-positive pathogen Streptococcus pneumoniae occurs when cells become “competent”, a state that is induced in response to high extracellular concentrations of a secreted peptide signal called CSP (Competence Stimulating Peptide) encoded by the comC locus. Two main CSP signal types (pherotypes) are known to dominate the pherotype diversity across strains. Using 4,089 fully sequenced pneumococcal genomes, we confirm that pneumococcal populations are highly genetically structured and that there is significant variation among diverged populations in pherotype frequencies; most carry only a single pherotype. Moreover, we find that the relative frequencies of the two dominant pherotypes significantly vary within a small range across geographical sites. It has been variously proposed that pherotypes either promote genetic exchange among cells expressing the same pherotype, or conversely that they promote recombination between strains bearing different pherotypes. We attempt to distinguish these hypotheses using a bioinformatics approach by estimating recombination frequencies within and between pherotypes across 4,089 full genomes. Despite underlying population structure, we observe extensive recombination between populations; additionally, we found significantly higher (although marginal) rates of genetic exchange between strains expressing different pherotypes than among isolates carrying the same pherotype. Our results indicate that pherotypes do not restrict, and may even slightly facilitate, recombination between strains; however, these marginal effects suggest the more likely possibility that the cause of CSP polymorphism lies outside of its effects on transformation. Our results suggest that the CSP balanced polymorphism does not causally underlie population differentiation. Therefore, when strains carrying different pherotypes encounter one another during co-colonization, genetic exchange can occur without restriction

Pherotype Polymorphism in Streptococcus pneumoniae Has No Obvious Effects on Population Structure and Recombination.

Natural transformation in the Gram-positive pathogen Streptococcus pneumoniae occurs when cells become "competent," a state that is induced in response to high extracellular concentrations of a secreted peptide signal called competence stimulating peptide (CSP) encoded by the comC locus. Two main CSP signal types (pherotypes) are known to dominate the pherotype diversity across strains. Using 4,089 fully sequenced pneumococcal genomes, we confirm that pneumococcal populations are highly genetically structured and that there is significant variation among diverged populations in pherotype frequencies; most carry only a single pherotype. Moreover, we find that the relative frequencies of the two dominant pherotypes significantly vary within a small range across geographical sites. It has been variously proposed that pherotypes either promote genetic exchange among cells expressing the same pherotype, or conversely that they promote recombination between strains bearing different pherotypes. We attempt to distinguish these hypotheses using a bioinformatics approach by estimating recombination frequencies within and between pherotypes across 4,089 full genomes. Despite underlying population structure, we observe extensive recombination between populations; additionally, we found significantly higher (although marginal) rates of genetic exchange between strains expressing different pherotypes than among isolates carrying the same pherotype. Our results indicate that pherotypes do not restrict, and may even slightly facilitate, recombination between strains; however, these marginal effects suggest the more likely possibility that the cause of CSP polymorphism lies outside of its effects on transformation. Our results suggest that the CSP balanced polymorphism does not causally underlie population differentiation. Therefore, when strains carrying different pherotypes encounter one another during cocolonization, genetic exchange can occur without restriction

Black-White Differences in Pregnancy Desire During the Transition to Adulthood

This article explores race differences in the desire to avoid pregnancy or become pregnant using survey data from a random sample of 914 young women (ages 18-22) living in a Michigan county and semi-structured interviews with a subsample of 60 of the women. In the survey data, desire for pregnancy, indifference, and ambivalence are very rare but are more prevalent among Black women than White women. In the semi-structured interviews, although few women described fatalistic beliefs or lack of planning for future pregnancies, Black and White women did so equally often. Women more often described fatalistic beliefs and lack of planning when retrospectively describing their past than when prospectively describing their future. Using the survey data to compare prospective desires for a future pregnancy with women\u27s recollections of those desires after they conceived, more Black women shifted positive than shifted negative, and Black women were more likely to shift positive than White women-that is, Black women do not differentially retrospectively overreport prospectively desired pregnancies as having been undesired before conception. Young women\u27s consistent (over repeated interviews) prospective expression of strong desire to avoid pregnancy and correspondingly weak desire for pregnancy, along with the similarity of Black and White women\u27s pregnancy plans, lead us to conclude that a planning paradigm -in which young women are encouraged and supported in implementing their pregnancy desires-is probably appropriate for the vast majority of young women and, most importantly, is similarly appropriate for Black and White young women

Clinical Validation of a Rapid Variant-Proof RT-RPA Assay for the Detection of SARS-CoV-2

The COVID-19 pandemic has unveiled a pressing need to expand the diagnostic landscape to permit high-volume testing in peak demand. Rapid nucleic acid testing based on isothermal amplification is a viable alternative to real-time reverse transcription polymerase chain reaction (RT-PCR) and can help close this gap. With the emergence of SARS-CoV-2 variants of concern, clinical validation of rapid molecular tests needs to demonstrate their ability to detect known variants, an essential requirement for a robust pan-SARS-CoV-2 assay. To date, there has been no clinical validation of reverse transcription recombinase polymerase amplification (RT-RPA) assays for SARS-CoV-2 variants. We performed a clinical validation of a one-pot multi-gene RT-RPA assay with the E and RdRP genes of SARS-CoV-2 as targets. The assay was validated with 91 nasopharyngeal samples, with a full range of viral loads, collected at University College London Hospitals. Moreover, the assay was tested with previously sequenced clinical samples, including eleven lineages of SARS-CoV-2. The rapid (20 min) RT-RPA assay showed high sensitivity and specificity, equal to 96% and 97%, respectively, compared to gold standard real-time RT-PCR. The assay did not show cross-reactivity with the panel of respiratory pathogens tested. We also report on a semi-quantitative analysis of the RT-RPA results with correlation to viral load equivalents. Furthermore, the assay could detect all eleven SARS-CoV-2 lineages tested, including four variants of concern (Alpha, Beta, Delta, and Omicron). This variant-proof SARS-CoV-2 assay offers a significantly faster and simpler alternative to RT-PCR, delivering sensitive and specific results with clinical samples

Late Paleocene event chronology: unconformities, not diachrony

The chronology of the events associated with the late Paleocene thermal maximum (LPTM, Chron C24r) has been established through the construction of a composite reference section that involved chemomagnetobiostratigraphic correlations and assumed minimum diachrony of biostratigraphic events. On this basis, discrepancies between correlations in different sections were explained by inferred unconformities. However, diachrony between distant sections cannot be ruled out. We report here on two geographically close sections drilled onshore New Jersey that yield different records of chemomagnetobiostratigraphic correlations in the interval representing Chron C24r. Because of their proximity (approximately 40 km apart), diachrony of biostratigraphic events between the two sections can be ruled out. In contrast, the marked lithologic disconformities in the sections explain well the different records of events. We thus conclude that the current relative chronology for Chron C24r is firmly based and that the upper Paleocene-lower Eocene stratigraphic record yields multiple unconformities, with Subzone NP9b rarely sampled. We examine the implications that undeciphered unconformities may have on the identification of proxies for paleoceanographic reconstruction, in particular with regard to the identification of the carbon isotope excursion (CIE) that reflects a dramatic latest Paleocene disturbance of the carbon cycle. We propose biostratigraphic means (short-lived calcareous nannoplankton and planktonic foraminifera taxa) that permit the unequivocal identification of the CIE not only in the oceanic realm but also in neritic settings